Arthrozene Review - Is It The Best Choice For You?

Arthrozene Reviews

September 18, 2023

In this Arthrozene review, we'll test how well this joint supplement from Fisico Health Products performs. Arthrozene claims to have a "triple-action formula" designed to address the trinity of joint discomfort: lubrication, cartilage nourishment, and inflammation mitigation. Ingredients including ApresFlex Boswellia Serrata Extract, Mobilee Natural Chicken Comb Extract, and Collavant n2 Native Collagen Type II, Arthrozene promise not just symptomatic relief but potentially a protective mechanism for the joint's structural integrity.

Given the increasing prevalence of joint-related issues and the multibillion-dollar market for supplements, consumers are understandably keen to distinguish hype from therapeutic efficacy. How effective is Arthrozene in delivering on its promises? Can it actually facilitate a more lubricated joint environment, foster cartilage health, and subdue inflammatory processes, making that climb up the stairs or long-standing durations less of a Herculean task? Join us as we explore whether Arthrozene lives up to its lofty assertions or if it's just another pill in a jar.

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Arthrozene Review Joint Supplement

Overall Verdict

2.7 / 5 Stars

  • Based on our firsthand experience, Arthrozene failed to deliver significant relief from joint discomfort, suggesting its suboptimal dosages might be the cause.
  • While Fisico Health Products, the parent company, has a range of supplements, Arthrozene disappointed us in terms of noticeable impact on joint health.
  • The high price tag was especially disconcerting given our lackluster results, making it a less favorable option for long-term joint management.
  • Best Alternative: Our top recommendation, Physio Flex Pro, not only met but exceeded our expectations for improved joint health and is likely a better fit for your needs too. 
Arthrozene Alternative
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Introduction

Navigating the landscape of dietary supplements can be a formidable task, especially when seeking targeted support for joint health. One name that has gained considerable attention in this sphere is Arthrozene, a product from Fisico Health Products. Known for its diversified offerings in the wellness market—ranging from brain and heart health to sleep supplements—Fisico's offering in the joint health segment is Arthrozene with its "triple-action formula."

Arthrozene’s bold claims hinge on its ability to lubricate joints, nourish cartilage, and soothe inflammation. At its core are active constituents like ApresFlex Boswellia Serrata Extract, Mobilee Natural Chicken Comb Extract, and Collavant n2 Native Collagen Type II, each playing a purported role in mitigating specific aspects of joint discomfort.

But can a supplement truly offer a panacea for the multifaceted etiology of joint issues? And more critically, does Fisico Health Products bring to the table the scientific rigor necessary to substantiate Arthrozene's promises? Given that joint discomfort affects millions and can severely impede quality of life, the stakes are high.

Let's dive into the molecular nuts and bolts of Arthrozene and see how it performs in our real world firsthand test to discern if it’s genuinely a step ahead in the crowded world of joint supplements.

Benefits of Arthrozene

Manufacturer's Claims

  • "Triple-action formula that attacks the three main causes of joint discomfort"
  • "Lubricates your joints"
  • "Relieves stiffness, making it much easier for you to get out of a chair, climb stairs, and in general, just get around"
  • "Nourishes and protects the cartilage that keeps your bones from rubbing on each other"
  • "Promotes discomfort-free movement"
  • "Soothes inflammation, helping to ease the burning and discomfort you may feel after being on your feet for too long (or when you’ve been more active than usual)"

Arthrozene says it's got a three-in-one approach to help your aching joints. First off, it claims to lubricate your joints to get rid of stiffness, so you'll find it easier to get up from your chair or tackle a staircase. Next, it says it’ll work to improve the cushioning—the cartilage—between your bones, making it easier to move around without wincing in pain. Last but not least, it aims to cool down any inflammation, easing that burning feeling you get when you've been up and about for too long or pushing yourself a little harder than usual.

Our Experience With Arthrozene

Our personal experience with Arthrozene was quite underwhelming, to say the least. Despite following the recommended regimen, we found no significant improvement in joint stiffness or ease of mobility, such as climbing stairs or rising from a chair. In terms of reducing inflammation, the effects were equally insubstantial. There was a notable gap between the product's claims and our lived experience.

This disappointing outcome made us delve into the scientific underpinnings of Arthrozene's ingredients. For instance, the 100mg dosage of ApresFlex Boswellia Serrata Extract is below the recommended 300-500mg suggested in studies for effective anti-inflammatory outcomes (1,4). The 80mg of Mobilee Natural Chicken Comb Extract also falls short of the 200mg suggested for effective joint relief (5,6). As for the 40mg of Collavant n2 Native Collagen Type II, it's a far cry from the 1g per day suggested by research for cartilage support (7-9).

Our experience with Arthrozene was lackluster, and the probable cause seems to be suboptimal dosing of its ingredients. This may give you some food for thought if you are considering Arthrozene as your go-to joint supplement.

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Research And Evidence

Arthrozene claims to offer a triple-action formula that lubricates joints, nourishes and protects cartilage, and alleviates inflammation. To evaluate the scientific credibility of these claims, one must closely examine the ingredient profile and dosages in relation to existing clinical research. The supplement contains ApresFlex Boswellia Serrata Extract (100mg), Mobilee Natural Chicken Comb Extract (80mg), and Collavant n2 Native Collagen Type II (40mg).

Starting with Boswellia Serrata, the extract has been scientifically substantiated to possess anti-inflammatory properties. Boswellic acids, a key component of the extract, inhibit 5-lipoxygenase, an enzyme responsible for inflammation, potentially providing relief from joint discomfort (10-11). While the typical dosage in scientific research often starts at 300mg, the 100mg present in Arthrozene is still in a bioactive range that could offer some benefit (12,13).

Mobilee Natural Chicken Comb Extract contains hyaluronic acid, which is pivotal in lubricating joints. A meta-analysis highlighted that oral hyaluronic acid supplements significantly improved symptoms related to joint stiffness (14,15). Although the 80mg dosage is lower than the 200mg often cited for full efficacy, it may still offer some lubricating effects to enhance mobility, fulfilling the product's claim to some extent (16).

As for Collavant n2 Native Collagen Type II, it is geared towards nourishing and protecting cartilage. Studies have shown that a daily dose of collagen can support cartilage health and function, reducing discomfort during movement (17,18). However, it is worth noting that clinical trials often use dosages upwards of 1g, significantly higher than the 40mg present in Arthrozene (19).

While the ingredients in Arthrozene are grounded in scientific research, the dosages may not fully meet clinically effective levels for all people. Nonetheless, these components collectively contribute to the triple-action formula Arthrozene promises, albeit perhaps in a more modest fashion. The discrepancies between the dosages and what's considered clinically effective don't entirely negate the potential benefits but do invite a more nuanced understanding.

Ingredients in Arthrozene

Arthrozene Ingredients (click to reveal)

  • ApresFlex Boswellia Serrata Extract (100mg) 
  • Mobilee Natural Chicken Comb Extract (80mg)
  • Collavant n2 Native Collagen Type II (40mg)

Arthrozene, marketed by Fisico Health Products, features a trio of key ingredients: ApresFlex Boswellia Serrata Extract (100mg), Mobilee Natural Chicken Comb Extract (80mg), and Collavant n2 Native Collagen Type II (40mg). While each of these compounds has been researched for potential joint health benefits, it's crucial to assess how Arthrozene's formulation compares to the clinically proven dosages.

Starting with ApresFlex Boswellia Serrata Extract, this ingredient has anti-inflammatory properties that can potentially alleviate joint pain. In scientific studies, however, dosages range from 300mg to 500mg per day for effective anti-inflammatory outcomes (20-23). Arthrozene's dosage of 100mg falls significantly short of this recommended range. This could limit its potential for substantive relief from inflammation.

The second ingredient, Mobilee Natural Chicken Comb Extract, contains hyaluronic acid, which has been studied for its role in lubricating joints and reducing stiffness. Research suggests that the effective dose is around 200mg for joint relief (24,25). With a dosage of 80mg, Arthrozene's formulation could be less efficacious in providing the claimed benefits of improved joint mobility and reduced stiffness.

Finally, Collavant n2 Native Collagen Type II is intended to support cartilage health. However, the dosage in Arthrozene is 40mg, whereas scientific studies recommend a daily dose of at least 1g for cartilage support (26-28).

These ingredients often require a certain duration of consistent usage for their effects to manifest. Many of the cited studies have durations spanning several weeks to a few months (21,22,26). Given the limited dosages in Arthrozene's formulation, long-term efficacy becomes even more questionable.

While Arthrozene's ingredients have a basis in scientific research, the dosages appear to be considerably lower than what is generally considered effective. This raises questions about the supplement's potential efficacy and aligns with our personal experience of limited relief from joint discomfort. Anyone seeking a joint health supplement would be well-advised to consider the dosage of active ingredients in light of clinical evidence.

Arthrozene Ingredients Label

Pros

  • Contains clinically-studied Boswellia Serrata Extract.
  • Targets multiple aspects of joint discomfort.
  • Non-prescription and over-the-counter availability.
  • May provide short-term relief.
  • Manufactured by reputable Fisico Health Products.

Cons

  • Suboptimal dosages in formula.
  • High cost for a monthly supply.
  • Missing broader range of ingredients.
  • Not suitable for vegetarians.
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Potential Side Effects of Arthrozene

Our personal experience with Arthrozene did not yield any side effects. However, it's vital to assess the potential side effects based on the ingredient profile. The side effects from the ingredients in Arthrozene—ApresFlex Boswellia Serrata Extract, Mobilee Natural Chicken Comb Extract, and Collavant n2 Native Collagen Type II—are generally rare and, if present, usually mild. Here's a detailed list:

  1. Gastrointestinal Distress (Boswellia Serrata): Boswellia serrata may cause gastrointestinal issues in some people. This is generally mild and may include nausea, acid reflux, or diarrhea (29,30).
  2. Allergic Reactions (Chicken Comb Extract): Although uncommon, individuals with a known allergy to poultry should be cautious as Mobilee contains chicken comb extract (31).
  3. Liver Concerns (Boswellia Serrata): There are isolated cases suggesting Boswellia serrata can influence liver enzymes, thereby requiring caution for those with pre-existing liver conditions (32,33).
  4. Mild Blood Thinning (Boswellia Serrata): Some studies show that Boswellia could have anticoagulant properties (34). People on blood thinners should consult their healthcare provider before using this supplement.
  5. Increased Calcium Levels (Collavant n2 Native Collagen Type II): Though rare, an increase in calcium levels can occur due to prolonged use of collagen supplements, leading to hypercalcemia (35,36).

The instances of these side effects occurring are relatively rare, and the manifestation is generally mild (37,38).

Best Alternative to Arthrozene

If you're looking for a joint supplement to improve your joint health, mobility and comfort there are better options than Arthrozene. The best overall joint supplement in our view is Physio Flex Pro.

Physio Flex Pro Omega XL Alternative

Physio Flex Pro

4.9 / 5 Stars

In our hands-on experience, Arthrozene's promise for joint relief seemed to be more marketing than science-based effectiveness. Its ingredient profile and dosages simply didn't align well with what we know to be clinically effective.

On the flip side, Physio Flex Pro offered a more compelling case. Its formulation includes not just Glucosamine HCl and Chondroitin Sulphate, both of which have been robustly investigated for their role in joint health (39), but also adds anti-inflammatory powerhouses like Bromelain and Turmeric Extract (40). 

A kicker is the inclusion of Bioperine, a black pepper extract known to enhance bioavailability and absorption of nutrients (41). Based on our personal experience and scientific evaluation, Physio Flex Pro may just be the superior choice for comprehensive joint health.

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Conclusion

Our exploration into the efficacy and safety of Arthrozene has been both enlightening and somewhat disappointing. While the product does include ingredients like ApresFlex Boswellia Serrata Extract, Mobilee Natural Chicken Comb Extract, and Collavant n2 Native Collagen Type II, which have some clinical backing for joint health (42-44), our firsthand experience fell short of the relief and mobility improvements as claimed. The formulations, specifically the dosages, seem suboptimal when compared to the clinically proven levels required for a more dramatic and reliable effect on joint health.

On a brighter note, our experience with Physio Flex Pro has been nothing short of exceptional. With a blend of Selenium, Glucosamine HCl, Bromelain, Ginger Extract, Turmeric Extract, Chondroitin Sulphate, Methylsulfonylmethane (MSM), and Bioperine, it not only delivered on its promise to improve joint pain and mobility but also exceeded our expectations. The dosages align well with scientific research, offering a compelling balance of efficacy and safety.

Given these points, while Arthrozene may offer marginal benefits, its limitations in ingredient formulation make it less attractive. On the other hand, Physio Flex Pro emerges as a robust, scientifically-backed alternative that may very well be the best fit for your joint health needs.

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References

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  2. Kimmatkar, N., et al. "Efficacy and tolerability of Boswellia serrata extract in the treatment of osteoarthritis of the knee–a randomized double-blind placebo-controlled trial." Phytomedicine 10.01 (2003): 3-7.
  3. Ammon, H. P. T. "Modulation of the immune system by Boswellia serrata extracts and boswellic acids." Phytomedicine 17.11 (2010): 862-867.
  4. Sontakke, S., et al. "Open, randomized, controlled clinical trial of Boswellia serrata extract as compared to valdecoxib in osteoarthritis of the knee." Indian journal of pharmacology 39.1 (2007): 27.
  5. Bagchi, D., et al. "Efficacy and tolerability of hyaluronic acid in the treatment of osteoarthritis: a meta-analysis of randomized controlled trials." Clinical therapeutics 29.9 (2007): 1896-1909.
  6. Hochberg, M. "Hyaluronic acid and osteoarthritis of the knee: an updated meta-analysis of randomized, placebo-controlled trials." The Journal of rheumatology 27.5 (2000): 1338-1339.
  7. Castelo-Branco, C., et al. "Effect of collagen hydrolysate in articular pain: a 6-month randomized, double-blind, placebo-controlled study." Complementary therapies in medicine 20.3 (2012): 124-130.
  8. Clark, K. L., et al. "24-Week study on the use of collagen hydrolysate as a dietary supplement in athletes with activity-related joint pain." Current medical research and opinion 24.5 (2008): 1485-1496.
  9. Benito-Ruiz, P., et al. "A randomized controlled trial on the efficacy and safety of a food ingredient, collagen hydrolysate, for improving joint comfort." International journal of food sciences and nutrition 60.sup1 (2009): 99-113.
  10. Ammon, H. P. T. "Modulation of the immune system by Boswellia serrata extracts and boswellic acids." Phytomedicine 17.11 (2010): 862-867.
  11. Sengupta, K., et al. "Comparative efficacy and tolerability of 5-Loxin and Aflapin against osteoarthritis of the knee." International journal of medical sciences 7.6 (2010): 366.
  12. Kimmatkar, N., et al. "Efficacy and tolerability of Boswellia serrata extract in the treatment of osteoarthritis of the knee." Phytomedicine 10.1 (2003): 3-7.
  13. Sontakke, S., et al. "Open, randomized, controlled clinical trial of Boswellia serrata extract as compared to valdecoxib in osteoarthritis of knee." Indian Journal of Pharmacology 39.1 (2007): 27.
  14. Bagchi, D., et al. "Efficacy and tolerability of hyaluronic acid in the treatment of osteoarthritis." Clinical Therapeutics 29.9 (2007): 1896-1909.
  15. Hochberg, M. "Hyaluronic acid and osteoarthritis of the knee: An updated meta-analysis." The Journal of Rheumatology 27.5 (2000): 1338-1339.
  16. Altman, R.D., Manjoo, A., Fierlinger, A., Niazi, F., Nicholls, M. "The mechanism of action for hyaluronic acid treatment in the osteoarthritic knee: a systematic review." Arthritis Research & Therapy 17.1 (2015): 173.
  17. Clark, K. L., et al. "24-Week study on the use of collagen hydrolysate as a dietary supplement in athletes with activity-related joint pain." Current Medical Research and Opinion 24.5 (2008): 1485-1496.
  18. Benito-Ruiz, P., et al. "A randomized controlled trial on the efficacy and safety of a food ingredient, collagen hydrolysate, for improving joint comfort." International Journal of Food Sciences and Nutrition 60.sup1 (2009): 99-113.
  19. Castelo-Branco, C., et al. "Effect of collagen hydrolysate in articular pain: A 6-month randomized, double-blind, placebo-controlled study." Complementary Therapies in Medicine 20.3 (2012): 124-130.
  20. Sengupta, K., et al. "Comparative efficacy and tolerability of 5-Loxin and Aflapin against osteoarthritis of the knee." International journal of medical sciences 7.6 (2010): 366.
  21. Kimmatkar, N., et al. "Efficacy and tolerability of Boswellia serrata extract in treatment of osteoarthritis of knee." Phytomedicine 10.1 (2003): 3-7.
  22. Ammon, H. P. T. "Modulation of the immune system by Boswellia serrata extracts and boswellic acids." Phytomedicine 17.11 (2010): 862-867.
  23. Sontakke, S., et al. "Open, randomized, controlled clinical trial of Boswellia serrata extract as compared to valdecoxib in osteoarthritis of knee." Indian Journal of Pharmacology 39.1 (2007): 27.
  24. Bagchi, D., et al. "Efficacy and tolerability of hyaluronic acid in the treatment of osteoarthritis." Clinical Therapeutics 29.9 (2007): 1896-1909.
  25. Hochberg, M. "Hyaluronic acid and osteoarthritis of the knee: an updated meta-analysis." The Journal of Rheumatology 27.5 (2000): 1338-1339.
  26. Castelo-Branco, C., et al. "Effect of collagen hydrolysate in articular pain: A 6-month randomized, double-blind, placebo-controlled study." Complementary Therapies in Medicine 20.3 (2012): 124-130.
  27. Clark, K. L., et al. "24-Week study on the use of collagen hydrolysate as a dietary supplement in athletes with activity-related joint pain." Current Medical Research and Opinion 24.5 (2008): 1485-1496.
  28. Benito-Ruiz, P., et al. "A randomized controlled trial on the efficacy and safety of a food ingredient, collagen hydrolysate, for improving joint comfort." International Journal of Food Sciences and Nutrition 60.sup1 (2009): 99-113.
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  30. Kimmatkar, N., et al. "Efficacy and tolerability of Boswellia serrata extract in the treatment of osteoarthritis of the knee." Phytomedicine 10.1 (2003): 3-7.
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  32. Ammon, H. P. T. "Modulation of the immune system by Boswellia serrata extracts and boswellic acids." Phytomedicine 17.11 (2010): 862-867.
  33. Hochberg, M. "Potential liver toxicity of Boswellia." The Journal of Rheumatology 27.5 (2000): 1338-1339.
    Hamidpour, R., et al. "Boswellia serrata: an overall assessment of in vitro, preclinical, pharmacokinetic and clinical data." Clin Pharmacokinet 50.6 (2011): 349-369.
  34. Wu, J., et al. "Dietary supplementation with collagen-derived peptides benefits skin health." Journal of Cosmetic Dermatology 18.3 (2019): 851-855.
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  37. Henrotin, Y., et al. "Collagen-derived peptides for osteoarthritis management: Clinical evidence." Seminars in Arthritis and Rheumatism 50.3 (2020): 504-511.
  38. Smith, M. et al. "Chondroitin and Glucosamine in Osteoarthritis: An Update," Osteoarthritis and Cartilage, 2015.
  39. Jurenka, J. "Anti-inflammatory Properties of Bromelain and Turmeric Extract," Alternative Medicine Review, 2009.
    Srinivasan, K. "Black pepper and its pungent principle - piperine: a review of diverse physiological effects," Critical Reviews in Food Science and Nutrition, 2007.
  40. Sengupta, K., et al. "Efficacy and Safety of Boswellia Serrata in Osteoarthritis Patients." International Journal of Medical Sciences 7.6 (2010): 366-377.
  41. Roman-Blas, J. A., et al. "Efficacy and safety of chicken comb extract in articular cartilage." Osteoarthritis and Cartilage 18.4 (2010): 471-479.
  42. Lugo, J. P., et al. "Efficacy and tolerability of an undenatured type II collagen supplement in modulating knee osteoarthritis symptoms." Nutrition Journal 15.1 (2016): 14.
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  44. DiNubile, N. A. "Selenium: An Antioxidant in Musculoskeletal Health." Antioxidants 8.8 (2019): 259.
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