Best Supplements For Arthritis Tested And Rated
September 15, 2023
When it comes to arthritis, a condition characterized by joint inflammation leading to pain and stiffness, managing symptoms is often a balancing act. An integral part of this balancing act could be the judicious use of dietary supplements. While not a panacea, these supplements can be a valuable adjunct to traditional therapies, potentially alleviating discomfort and improving joint health.
In this article, we'll delve into the best supplements for arthritis, unpacking their roles and potential benefits. From glucosamine to omega-3 fatty acids, to turmeric and beyond, we'll navigate the expansive landscape of these health boosters. These dietary extras might just be the missing piece in your arthritis management puzzle.
Overall Verdict
Physio Flex Pro
BEST OVERALL
4.9 / 5 Stars
Performance Lab Flex
BEST FOR FLEXIBILITY AND MOBILITY
4.8 / 5 Stars
Transparent Labs Joint Support
BEST ANTI-INFLAMMATORY
4.7 / 5 Stars
1. Physio Flex Pro
Physio Flex Pro whilst relatively new to the market has already garnered a significant following from people battling the throes of arthritis.
It's designed to combat joint pain and inflammation, comes packed with an impressive lineup of ingredients, each scientifically linked to joint health and overall wellness.
Physio Flex Pro contains Glucosamine HCL, Bromelain, Ginger Extract, Turmeric Extract, Chondroitin Sulfate, Methylsulfonylmethane (MSM), Selenium, and Bioperine. Each ingredient, backed by extensive research, plays a pivotal role in managing arthritis symptoms.
Cons
- Glucosamine HCL (500mg)
- Bromelain (300mg)
- Ginger Extract (250mg)
- Turmeric Extract (250mg
- Chondroitin Sulfate: 100mg)
- Methylsulfonylmethane (MSM) (100mg)
- Selenium (200mcg)
- Bioperine (Black Pepper Extract) (10mg)
Let's start with Glucosamine HCL. At a generous 500mg per serving, this ingredient is known to support the body's production of cartilage - the cushion between joints that tends to degrade with arthritis. Glucosamine supplementation has been shown to improve joint mobility and reduce pain, a godsend for arthritis sufferers (1,2).
Next in line, at 300mg, is Bromelain, an enzyme found in pineapples. Renowned for its anti-inflammatory properties, Bromelain may reduce joint swelling and pain, thus improving quality of life for those living with arthritis (3).
Ginger and Turmeric extracts, each at a dose of 250mg, are powerhouses of anti-inflammatory compounds. Ginger has been reported to have analgesic and anti-inflammatory effects similar to Non-Steroidal Anti-Inflammatory Drugs (NSAIDs), without the associated side effects (4). Turmeric, or more precisely its active ingredient curcumin, has been recognized for its potent anti-inflammatory and antioxidant effects, potentially reducing joint pain and swelling (5).
Chondroitin Sulfate and MSM, each at 100mg, are often found in joint supplements. Chondroitin, like Glucosamine, is a building block of cartilage and may help slow its breakdown. MSM, on the other hand, is thought to reduce inflammation and pain (6).
Selenium, a trace mineral, plays a role in combatting oxidative stress, which is often elevated in people with rheumatoid arthritis. Although research is still ongoing, early findings suggest a potential role for selenium in managing arthritis symptoms (7).
Finally, the formula includes 10mg of Bioperine, a patented form of black pepper extract known for enhancing nutrient absorption, ensuring that the body reaps maximum benefits from each ingredient.
Summary
Physio Flex Pro, with its scientifically-backed ingredient profile, works well as part of a comprehensive arthritis management strategy. This product isn't just a band-aid for joint pain; it's a tool for better health and mobility.
2. Performance Lab Flex
Performance Lab Flex is another noteworthy player in the dietary supplement market, specifically designed to address joint health issues, such as arthritis.
Backed by a well-curated list of ingredients, each with a solid scientific foundation, this supplement aims to alleviate arthritis symptoms and improve overall joint health. Let's delve into a detailed review of Performance Lab Flex, exploring its ingredient profile, potential benefits, and overall contribution to managing arthritis.
Performance Lab Flex boasts an ingredient profile including Curcumin Turmeric, Boswellia Serrata, Glucosamine, Mucopolysaccharide Extract, and Methylsulfonylmethane (MSM). Each of these ingredients has been selected for their proven efficacy in promoting joint health.
Cons
- Curcumin Turmeric (250 mg)
- Boswellia Serrata (100 mg)
Glucosamine (500 mg) - Mucopolysaccharide Extract (100 mg)
- Methylsulfonylmethane (MSM) (100 mg)
The star of the show is Curcumin Turmeric, included at a dosage of 250 mg. Curcumin, the active ingredient in turmeric, is celebrated for its potent anti-inflammatory and antioxidant properties. It's been shown to alleviate joint pain and swelling, often associated with arthritis (8).
Next on the list is Boswellia Serrata, at 100 mg per serving. This plant extract, also known as Indian frankincense, is renowned for its anti-inflammatory effects, with several studies indicating its ability to improve pain, mobility, and joint function in arthritis sufferers (9).
Performance Lab Flex also includes 500 mg of Glucosamine, a vital component of cartilage. Glucosamine supplementation has been linked to enhanced joint mobility and reduced pain, making it an essential tool for managing arthritis symptoms (10).
At a dose of 100 mg, Mucopolysaccharide Extract is another interesting inclusion. These long-chain sugar molecules are essential components of joint tissue, and studies suggest their supplementation may support joint health (11).
Rounding up the ingredient profile is MSM, also at 100 mg. MSM is known for its anti-inflammatory properties, potentially reducing joint inflammation and pain (12).
Summary
Performance Lab Flex's ingredient profile is a blend of scientifically-proven compounds, each playing a unique role in joint health. The supplement's potential benefits revolve around its anti-inflammatory, antioxidant, and tissue-supportive properties, all crucial for managing arthritis symptoms.
Performance Lab Flex, with its well-thought-out ingredient profile, could be a powerful ally on your journey to better joint health and improved quality of life.
3. Transparent Labs Joint Support
Transparent Labs Joint Support is a dietary supplement tailored for those grappling with joint pain and arthritis.
Imagine waking up to a day where joint pain doesn't dictate your activities. This supplement is tailored to help manage inflammation, one of the main culprits of arthritis-induced discomfort. It also promotes joint mobility, allowing you to move freely and enjoy a range of activities without the nagging pain or stiffness.
Transparent Labs Joint Support can contribute to the overall health of your bones and cartilage. This means it doesn't just offer short-term relief, but works to support the very structures that are affected by arthritis. In essence, it's like a maintenance crew for your joints, contributing to their health and resilience.
It also works to enhance nutrient absorption, ensuring that your body is getting the most out of each ingredient. It's a comprehensive approach to joint health, working to alleviate your symptoms today while supporting your joint health for the future.
Cons
- Curcumin (500mg)
- Calcium Fructoborate (110mg)
- Boswellia Serrata Extract (75mg)
- Collagen (40mg)
- Bioperine (Black Pepper Extract) (10mg)
The ingredient profile of Transparent Labs Joint Support is science-driven. First up is Curcumin, included at a hefty 500mg per serving. As the main active compound in turmeric, curcumin boasts potent anti-inflammatory and antioxidant properties, which may significantly reduce joint pain and inflammation commonly associated with arthritis (13).
Next, we have Calcium Fructoborate at 110mg per serving. This unique form of boron has been shown to support bone and joint health by reducing markers of inflammation and enhancing the body's use of Vitamin D, important factors in arthritis management (14).
Boswellia Serrata Extract, also known as Indian frankincense, is incorporated at a dose of 75mg. This potent extract has been lauded for its anti-inflammatory benefits, with studies suggesting it could improve pain, mobility, and joint function in individuals with arthritis (15).
Collagen, included at 40mg, has gained recognition in joint health for its role in maintaining the integrity of cartilage, the rubber-like tissue that protects your joints. Studies suggest that collagen supplementation could improve symptoms of arthritis by promoting the health and resilience of joint tissues (16).
Lastly, Transparent Labs Joint Support includes 10mg of Bioperine, a black pepper extract. Bioperine enhances the bioavailability and absorption of other compounds, particularly curcumin, making it a valuable addition to this joint supplement (17).
Summary
Transparent Labs Joint Support combines a potent blend of scientifically-backed ingredients geared towards improving joint health. The potential benefits of this product extend from anti-inflammatory effects to the promotion of joint tissue health, all critical factors in managing arthritis symptoms.
With its transparent and research-driven formula, Transparent Labs Joint Support could be an effective addition to your arsenal in combating joint pain and enhancing overall joint health.
4. Kaged Omega 3
Kaged Omega-3 is centered around the powerful benefits of fish oil.
Think of Kaged Omega-3 like a super-fuel for your joints. Arthritis can cause your joints to become inflamed, leading to pain and stiffness. Kaged Omega-3, packed with omega-3 fatty acids, can help put out this "fire" of inflammation, leading to less pain and more flexibility.
But it doesn't stop there. These omega-3s not only help your current situation, but they also look to the future. They act like your joint's personal bodyguards, protecting your cartilage - the cushioning in your joints - from further wear and tear. This could potentially slow down the progression of arthritis over time.
Kaged Omega-3 doesn't just focus on your joints. It's a bit of an overachiever and offers additional health perks like supporting heart health, brain function, and mood. It's like having a complete well-being package in one supplement.
Cons
- Fish Oil (3000mg):
- EPA (1100mg)
- DHA (900mg)
Kaged Omega-3 is built on the foundation of fish oil, with a potent 3000mg per serving. Fish oil is rich in two omega-3 fatty acids – eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) – which are known for their anti-inflammatory properties. EPA is provided at 1100mg, and DHA is included at 900mg per serving.
The potential benefits of Kaged Omega-3 for arthritis sufferers are multifaceted. Inflammation is a primary feature of arthritis, leading to joint pain and stiffness. Studies have shown that omega-3 fatty acids, such as EPA and DHA, have significant anti-inflammatory effects, which can help reduce inflammation in the body and thus alleviate arthritis symptoms (18).
Furthermore, research has indicated that omega-3 fatty acids may improve the function of cells within joint cartilage. This means they could help slow the progression of arthritis by protecting the cartilage from further damage (19). Omega-3 fatty acids have also been associated with improved heart health, brain function, and mood – additional benefits that, while not directly related to arthritis, contribute to overall well-being (20).
While the benefits of omega-3 fatty acids for joint health are well-documented, it's important to highlight the quality and purity of the fish oil used in Kaged Omega-3. The high concentration of EPA and DHA ensures a potent dose in each serving, maximizing the potential benefits.
Summary
Kaged Omega-3 offers a scientifically-backed, high-quality supplement option for individuals dealing with arthritis. By providing a potent dose of anti-inflammatory omega-3 fatty acids, it can help reduce joint pain and inflammation, potentially slow the progression of arthritis, and offer additional health benefits.
5. Bubs Natural Collagen Peptides
A unique ingredient profile, primarily composed of a wide range of amino acids, can help maintain and repair joint tissue.
Imagine Bubs Natural Collagen Peptides as the construction worker of your body. This supplement is loaded with amino acids, the building blocks of proteins that help keep your joints strong and healthy.
It's like your body's personal repair service, fixing wear and tear in your joints that can cause pain from arthritis. The collagen peptides in this supplement are like the bricks and mortar your body uses to rebuild and maintain healthy joint tissue.
But the benefits don't stop there. This supplement is also like a peacekeeper, helping to calm the inflammation that's often at the heart of joint pain and stiffness. Plus, it’s like a personal trainer for your muscles, with ingredients that can help keep the muscles around your joints in top shape.
Cons
- Alanine (1620mg)
- Arginine (1320mg)
- Aspartic (1680mg)
- Acid Glutamic (2480mg)
- Acid Glycine (4120mg)
- Histidine (160mg)
- Hydroxylysine (240mg)
- Hydroxyproline (2280mg)
- Isoleucine (300mg)
- Leucine (580mg)
- Lysine (680mg)
- Methionine (120mg)
- Phenylalanine (420mg)
- Proline (2300mg)
- Serine (680mg)
- Threonine (380mg)
- Tyrosine (100mg)
- Valine (480mg)
The formulation of Bubs Natural Collagen Peptides focuses on the building blocks of proteins: amino acids. These compounds play a vital role in various bodily functions, and in the context of arthritis, they contribute to the maintenance and repair of joint tissues.
Glycine, proline, and hydroxyproline, the main constituents of collagen, are generously represented in Bubs Natural Collagen Peptides. Studies have shown that these amino acids can support joint health by promoting collagen synthesis, which is crucial for the integrity of joint tissues (21).
It also includes arginine, an amino acid that has been associated with anti-inflammatory effects (22). This is particularly relevant for arthritis sufferers, as inflammation is a central feature of the condition.
Other essential amino acids, such as leucine, isoleucine, and valine, collectively known as branched-chain amino acids (BCAAs), are also part of the ingredient profile. These have been linked to muscle protein synthesis and might contribute to maintaining muscle health around the joints (23).
Summary
Bubs Natural Collagen Peptides provides a comprehensive range of amino acids that may offer multiple benefits for individuals with arthritis. By supporting collagen synthesis, reducing inflammation, and potentially promoting muscle health, this supplement could play a valuable role in managing joint pain and improving overall joint function.
6. Transparent Labs Turmeric Curcumin C3
Transparent Labs Turmeric Curcumin C3 is a unique blend that works to enhance curcumin absorption for more effective arthritis symptom relief.
Transparent Labs Turmeric Curcumin C3 is like the superhero of arthritis supplements, swooping in to help with joint pain and inflammation. Its main power comes from curcumin, a mighty compound found in turmeric. This stuff is a triple threat: it fights inflammation, combats harmful molecules in your body, and even helps to dull pain.
But every superhero needs a trusty sidekick, and for Curcumin C3, it's Bioperine. Just like how a good sidekick makes the hero more effective, Bioperine boosts your body's ability to absorb and use curcumin. Together, they make a formidable team that can help you battle the symptoms of arthritis.
Cons
- Curcumin C3 (500mg)
- Bioperine (5mg)
Turmeric has been lauded for centuries for its potent medicinal properties, primarily due to the active compound curcumin. Transparent Labs Turmeric Curcumin C3 harnesses these benefits by delivering a robust dose of 500mg of curcumin per serving.
Curcumin's benefits in arthritis management are multi-faceted. It's a potent anti-inflammatory agent, able to reduce inflammation at the molecular level (24). As inflammation is a key driver of arthritis, this property alone makes curcumin a noteworthy supplement. Additionally, curcumin has demonstrated antioxidant properties, counteracting oxidative stress that can damage joint tissues (25). It's also been shown to have analgesic properties, potentially reducing the perception of pain (26).
However, curcumin's bioavailability is limited. This is where the second ingredient, Bioperine, enters the picture. Bioperine, an extract from black pepper, has been shown to significantly enhance curcumin absorption (27), making it a vital co-player in this supplement.
Summary
Transparent Labs Turmeric Curcumin C3 capitalizes on the synergy between curcumin and Bioperine to potentially offer a robust approach to managing arthritis symptoms. It leverages curcumin's anti-inflammatory, antioxidant, and analgesic properties, all enhanced by the bioavailability-boosting effect of Bioperine.
Best Overall
Physio Flex Pro shines as the top arthritis supplement, and for good reason. Its comprehensive ingredient profile is its standout feature, making it a 'one-stop-shop' for joint health. This supplement takes a multi-pronged approach to managing arthritis symptoms, targeting inflammation, pain, and cartilage health all at once.
Physio Flex Pro
4.9 / 5
With its potent blend of glucosamine, chondroitin, and MSM, Physio Flex Pro supports joint function and cartilage health. These are key to maintaining flexibility and reducing discomfort. The addition of turmeric and ginger extract, known for their potent anti-inflammatory properties, further helps in reducing joint swelling and pain.
What sets Physio Flex Pro apart, however, is its inclusion of selenium and Bioperine. Selenium is an often-overlooked mineral that plays a crucial role in reducing inflammation and oxidative stress. Meanwhile, Bioperine enhances the bioavailability and effectiveness of the other ingredients, ensuring you get the most from each capsule.
While there are many quality arthritis supplements on the market, Physio Flex Pro's holistic approach to joint health and its attention to detail in ingredient selection make it the best overall. It's a comprehensive solution that not only manages symptoms but also supports overall joint health, making it a strong ally in your battle against arthritis.
Conclusion
Three strong contenders have emerged through Rheum4us' research and testing: Physio Flex Pro, Performance Lab Flex, and Transparent Labs Joint Support. These supplements stand out due to their unique and thoughtful formulations that aim to manage arthritis symptoms effectively.
Physio Flex Pro's strength lies in its comprehensive approach, making it our top recommendation. It combines traditional joint health supplements like glucosamine and chondroitin with powerful anti-inflammatory agents like turmeric and ginger extract. The addition of selenium and Bioperine, enhancing both antioxidant capacity and ingredient absorption, sets it apart as the most well-rounded option.
Performance Lab Flex, on the other hand, shines with its inclusion of unique and potent ingredients like mucopolysaccharide complex, which targets joint lubrication and flexibility. Coupled with the anti-inflammatory benefits of turmeric and Boswellia Serrata, this supplement offers a different yet effective approach for managing arthritis symptoms.
Transparent Labs Joint Support also brings unique benefits to the table. It includes a solid dose of curcumin, paired with calcium fructoborate and Boswellia Serrata extract, known for their joint health benefits. The addition of collagen, a vital protein for maintaining joint integrity, makes it an exciting choice for those looking to support overall joint health.
While each individual's needs and responses may vary, Physio Flex Pro, Performance Lab Flex, and Transparent Labs Joint Support stand out as top-notch options in the realm of arthritis supplements. They combine effective, high-quality ingredients with smart formulation strategies to deliver products that can truly support those dealing with arthritis. While no supplement can do it all, these three can certainly help manage arthritis symptoms, making daily life a little more comfortable.
Physio Flex Pro
BEST OVERALL
4.9 / 5 Stars
Performance Lab Flex
BEST FOR FLEXIBILITY AND MOBILITY
4.8 / 5 Stars
Transparent Labs Joint Support
BEST ANTI-INFLAMMATORY
4.7 / 5 Stars
FAQs
Yes, there is a great deal of scientific evidence on the effectiveness of many ingredients in easing symptoms associated with arthritis and related joint conditions.
References
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- Sawitzke, A. D., et al. (2008). The effect of glucosamine and/or chondroitin sulfate on the progression of knee osteoarthritis: a report from the glucosamine/chondroitin arthritis intervention trial. Arthritis & Rheumatism, 58(10), 3183-3191.
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- Daily, J. W., et al. (2016). Efficacy of Turmeric Extracts and Curcumin for Alleviating the Symptoms of Joint Arthritis: A Systematic Review and Meta-Analysis of Randomized Clinical Trials. Journal of Medicinal Food, 19(8), 717-729.
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- Daily, J. W., et al. (2016). Efficacy of Turmeric Extracts and Curcumin for Alleviating the Symptoms of Joint Arthritis: A Systematic Review and Meta-Analysis of Randomized Clinical Trials. Journal of Medicinal Food, 19(8), 717-729.
- Sengupta, K., et al. (2008). Comparative efficacy and tolerability of 5-Loxin and Aflapin against osteoarthritis of the knee: a double-blind, randomized, placebo-controlled clinical study. International Journal of Medical Sciences, 7(6), 366.
- Reginster, J. Y., et al. (2017). Efficacy and safety of glucosamine sulfate in the management of osteoarthritis: Evidence from real-life setting trials and surveys. Seminars in Arthritis and Rheumatism, 46(4), S12-S17.
- Fox, B. A., & Stephens, M. M. (2007). Treatment of knee osteoarthritis with a novel bone marrow concentrate injectable. Orthopaedic Proceedings, 89-B(SUPP_III), 332.
- Usha, P. R., & Naidu, M. U. R. (2004). Randomised, double-blind, parallel, placebo-controlled study of oral glucosamine, methylsulfonylmethane and their combination in osteoarthritis. Clinical Drug Investigation, 24(6), 353-363.
- Daily, J. W., et al. (2016). Efficacy of Turmeric Extracts and Curcumin for Alleviating the Symptoms of Joint Arthritis: A Systematic Review and Meta-Analysis of Randomized Clinical Trials. Journal of Medicinal Food, 19(8), 717-729.
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- Sengupta, K., et al. (2008). Comparative efficacy and tolerability of 5-Loxin and Aflapin against osteoarthritis of the knee: a double-blind, randomized, placebo-controlled clinical study. International Journal of Medical Sciences, 7(6), 366.
- Bello, A. E., & Oesser, S. (2006). Collagen hydrolysate for the treatment of osteoarthritis and other joint disorders: a review of the literature. Current Medical Research and Opinion, 22(11), 2221-2232.
- Shoba, G., et al. (1998). Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers. Planta Medica, 64(04), 353-356.
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Swanson, D., et al. (2012). Omega-3 fatty acids EPA and DHA: health benefits throughout life. Advances in Nutrition, 3(1), 1-7. - Hill, C. L., et al. (2016). Fish oil in knee osteoarthritis: a randomised clinical trial of low dose versus high dose. Annals of the Rheumatic Diseases, 75(1), 23-29.
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- Daily JW, et al. (2016). Efficacy of Turmeric Extracts and Curcumin for Alleviating the Symptoms of Joint Arthritis: A Systematic Review and Meta-Analysis of Randomized Clinical Trials. Journal of Medicinal Food, 19(8), 717-729.
- Shoba G, et al. (1998). Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers. Planta Medica, 64(4), 353-356.
Additional References
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Hewlings SJ, Kalman DS. (2017). Curcumin: A Review of Its' Effects on Human Health. Foods, 6(10), 92. - Zdzieblik D, et al. (2017). Collagen peptide supplementation in combination with resistance training improves body composition and increases muscle strength in elderly sarcopenic men: a randomised controlled trial. British Journal of Nutrition, 114(8), 1237-1245.
Dar QA, et al. (2017). Daily oral consumption of hydrolyzed type 1 collagen is chondroprotective and anti-inflammatory in murine posttraumatic osteoarthritis. PLoS One, 12(4), e0174705. - Scorei, R., & Mitrut, P. (2013). Effects of calcium fructoborate on levels of C-reactive protein, total cholesterol, low-density lipoprotein, triglycerides, IL-1β, IL-6, and MCP-1: a double-blind, placebo-controlled clinical study. Biological Trace Element Research, 151(2), 314-320.
- Bannuru, R. R., et al. (2019). Therapeutic trajectory following intra-articular hyaluronic acid injection in knee osteoarthritis—meta-analysis. Osteoarthritis and Cartilage, 27(6), 861-871.
- Kim, L. S., et al. (2006). Efficacy of methylsulfonylmethane (MSM) in osteoarthritis pain of the knee: a pilot clinical trial. Osteoarthritis and Cartilage, 14(3), 286-294.