Omega XL Review - Long-Term Test Results

Omega XL Reviews

October 21, 2024

In this review of Omega XL, we'll explore the effectiveness of this joint supplement, which is promoted as a solution for managing joint pain and inflammation associated with arthritis and daily wear and tear. Omega XL claims to provide relief by utilizing over 30 different fatty acids sourced from green-lipped mussels in New Zealand. We will break down the ingredient list, examine the research behind these fatty acids, and assess whether the product truly delivers on its promises.

We'll also look into the proprietary blend used in Omega XL, as the lack of specific dosage information raises questions about its clinical efficacy. To provide a well-rounded perspective, we’ll also look into alternative joint supplements that offer clearer formulations and clinically-backed doses, which might be more effective options for those seeking tangible relief and improved mobility.

Table of Contents: Quick Links
Omega XL Does It Work

Overall Verdict

2.7 / 5 Stars

  • Very Modest Benefits. Despite claims, Omega XL delivered minimal joint relief, with very modest improvements in mobility and pain reduction, likely due to its low dosage of active ingredients.
  • Low Dosage. The 300 mg proprietary blend is significantly underdosed compared to clinically effective amounts, limiting its potential to provide substantial joint health benefits.
  • Missing Clinically Proven Ingredients. Omega XL lacks important ingredients like glucosamine, chondroitin, and turmeric, all proven to support joint health and reduce inflammation effectively.
  • Lack of Transparency. The product’s proprietary blend does not disclose specific concentrations of omega fatty acids, making it difficult to verify the efficacy of its formulation.
  • Recommended Alternative. We recommend Physio Flex Pro, which consistently delivered great results during our testing. We like that it utilizes a scientifically-backed, comprehensive joint health formula.
Physio Flex Pro Omega XL Alternative
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What Is Omega XL?

OmegaXL is a joint supplement positioned as an advanced alternative to traditional omega-3 products, highlighting its blend derived from green-lipped mussel oil. Unlike standard fish oils that typically contain EPA and DHA, OmegaXL’s formula claims to be richer in fatty acids, presenting a more bioavailable option for joint, muscle, and mobility support. The brand emphasizes that its proprietary blend is clinically backed by over 35 years of research, asserting that it alleviates exercise-induced joint and muscle soreness.

The green-lipped mussels, the key ingredient, are sourced sustainably from New Zealand, ensuring the oil extract remains rich in a variety of free fatty acids beyond EPA and DHA. Notably, the product is marketed as easy to consume with no fishy aftertaste, setting it apart from traditional omega-3 supplements. Despite these claims, users may still need to consider if the supplement’s benefits are as substantial as stated, given that the research primarily highlights its potential rather than definitive results

Scientific Assessment of Omega XL's Claims

Claim 1: “XL Benefits Beyond Omega-3s - The ultimate joint health and mobility support supplement.”

OmegaXL claims to offer a superior source of omega-3s by using green-lipped mussel oil (GLMO) instead of standard fish oil, which typically contains EPA and DHA. Green-lipped mussels (Perna canaliculus) are known to contain a broader spectrum of omega fatty acids, including EPA, DHA, and other lipid mediators that may provide anti-inflammatory properties (1)(2). However, while these have shown potential in reducing joint inflammation, the concentration and dosage in OmegaXL’s proprietary blend (300 mg) are not disclosed in sufficient detail. Standard clinical studies recommend higher dosages (at least 1,200 mg of EPA and DHA combined) for effective anti-inflammatory action (3)(4). Therefore, the effectiveness of OmegaXL’s lower dosage remains uncertain without additional transparency on its fatty acid content (2).

Claim 2: “Mussels for Your Joints - Helps to relieve occasional exercise-related joint and muscle soreness.”

The proprietary blend claims to alleviate joint and muscle soreness through a more absorbable free fatty acid form. Research supports that GLMO may provide joint pain relief, potentially due to its eicosatetraenoic acid (ETA) content, which can inhibit inflammatory pathways (1). However, the clinical relevance of this benefit is dosage-dependent. A study on GLMO supplementation showed a reduction in osteoarthritis symptoms at dosages of 1,150 mg/day (3). Since OmegaXL’s proprietary blend contains only 300 mg per serving, the question remains whether such a low dosage can replicate these effects, particularly for exercise-induced soreness, as the studies typically involve higher doses (4).

Claim 3: “More than a Fish Oil - OmegaXL contains the oil extract from green-lipped mussels, not fish.”

OmegaXL tries to set itself apart from conventional fish oils by using green-lipped mussel oil, which contains over 30 free fatty acids, including EPA and DHA. Scientific evidence highlights that GLMO may provide additional benefits compared to standard fish oils due to its unique blend of omega-3s and other bioactive compounds (1)(5). However, the efficacy and concentration of these additional fatty acids are not well-documented. While it is true that these mussels offer a variety of lipid mediators that may support joint health, the proprietary nature of the blend in OmegaXL makes it difficult to verify whether its specific formulation provides superior benefits over traditional fish oils, especially considering the established and researched dosages for fish oil products (2).

Claim 4: “Get the Benefits, Without the Fishy Aftertaste - Convenient, small, and easy-to-swallow soft gel.”

OmegaXL promotes its soft gel as having no fishy aftertaste, which is often associated with fish oils. This is likely due to its use of GLMO, which does not produce the same oxidation products that can cause this effect (6). However, while the absence of a fishy aftertaste is a beneficial attribute, it does not necessarily translate to improved efficacy. The low dosage (300 mg per soft gel) may be convenient, but it may also limit the product's therapeutic potential, as higher amounts of EPA and DHA are generally needed for significant clinical benefits (3).

Claim 5: “Committed to Wellness - Great HealthWorks’ mission is to offer natural, science-based solutions.”

While the brand emphasizes its commitment to science-based products, it's crucial to note that clinical research specifically on OmegaXL is limited. The company references studies on green-lipped mussel oil, which indeed suggest potential benefits for joint health (1)(7). These studies often use specific dosages or formulations not necessarily equivalent to OmegaXL's proprietary blend. Without independent studies verifying the efficacy of OmegaXL’s exact formulation and dosage, it is difficult to validate its effectiveness solely based on its ingredient sourcing or general research on green-lipped mussels (2)(4).

OmegaXL’s green-lipped mussel oil offers a potentially advantageous profile for joint health beyond traditional omega-3 sources, but there are several scientific and dosage concerns. The low dosage of 300 mg per soft gel, alongside the lack of transparency on the concentrations of key fatty acids within the proprietary blend, makes it challenging to verify the product’s efficacy against exercise-related joint pain or overall mobility support. To substantiate its claims fully, OmegaXL would benefit from disclosing more information about its proprietary blend and conducting clinical trials specific to its formulation.

Our Experience With Omega XL

Our experience with OmegaXL was underwhelming, particularly when compared to the promises the brand makes. Whilst OmegaXL is marketed as a cutting-edge joint supplement, claiming benefits that supposedly go “beyond omega-3s” through the use of green-lipped mussel oil (GLMO), our real-world experience showed that the effects were muted and fell short of these claims.

Claim 1: “XL Benefits Beyond Omega-3s - The ultimate joint health and mobility support supplement.”

OmegaXL positions itself as a powerful alternative to standard omega-3 supplements, promoting benefits for joint, muscle, immune, and respiratory health. However, during our trial, these benefits were less pronounced than expected. The product contains 300 mg of a proprietary blend, which is significantly lower than the dosages used in clinical trials that have shown efficacy for GLMO (8). For instance, studies suggest that doses of 1,150 mg/day are necessary to achieve substantial anti-inflammatory effects and joint support (9). Given this discrepancy, it’s no surprise that our experience with OmegaXL’s impact on mobility and joint health was minimal.

Claim 2: “Mussels for Your Joints - Helps to relieve occasional exercise-related joint and muscle soreness.”

The brand claims that its formulation can reduce exercise-induced joint and muscle soreness due to its high absorbability. While OmegaXL’s green-lipped mussel oil does contain beneficial fatty acids like EPA, DHA, and ETA, which have anti-inflammatory properties (10), the low dosage per capsule made it difficult to notice any consistent relief. In our experience, OmegaXL’s effects were subtle and inconsistent, especially when compared to other supplements with higher concentrations of active ingredients (11).

Claim 3: “More than a Fish Oil - Contains oil extract from green-lipped mussels, not fish.”

OmegaXL markets itself as more than just a fish oil supplement by highlighting its GLMO as a richer, more potent source of omega-3s and other fatty acids (12). However, despite this supposed differentiation, the results were not significantly different from what we would expect from a standard, well-dosed fish oil supplement. The proprietary nature of the blend means that the exact concentrations of these fatty acids are not disclosed, making it hard to verify whether the product genuinely offers the superior benefits claimed (8).

Claim 4: “Get the Benefits, Without the Fishy Aftertaste - Convenient, small, and easy-to-swallow soft gel.”

One positive aspect of OmegaXL is its small, easy-to-swallow gel capsule, which indeed does not have the fishy aftertaste commonly associated with fish oil supplements (13). This made taking the product convenient, and it did not cause any digestive issues or aftertaste. However, whilst this is a useful feature, it does not make up for the lackluster joint health benefits.

Claim 5: “Committed to Wellness - Great HealthWorks’ mission is to offer natural, science-based solutions.”

The brand emphasizes its commitment to wellness and science-based solutions, yet the lack of transparency in the product's formulation and dosage information undermines this claim. While there is supportive research on GLMO’s benefits for joint health (14), the studies cited typically use much higher dosages than what OmegaXL provides. Without clinical evidence specifically verifying the efficacy of OmegaXL’s 300 mg proprietary blend, it is difficult to substantiate the brand’s claims about its product’s overall impact (15).

Ingredients in Omega XL

Omega XL Ingredients (click to reveal)

Proprietary Blend (300 mg):

  • Green-Lipped Mussel (Perna canaliculus) Oil Extract (PCSO-524®) containing Omega Fatty Acids
  • Extra Virgin Olive Oil
  • Pure Olive Oil
  • d-alpha Tocopherol (Vitamin E)

Other Ingredients:

  • Gelatin
  • Glycerin
  • Purified water

Omega XL is a joint supplement primarily featuring green-lipped mussel oil (GLMO), extra virgin olive oil, and d-alpha tocopherol (Vitamin E) as its key ingredients. To evaluate its effectiveness, it's essential to review the scientific evidence behind each of these ingredients and how their proven doses compare with the proprietary blend used in Omega XL.

1. Green-Lipped Mussel Oil (GLMO) - 300 mg Proprietary Blend

The central ingredient in Omega XL is GLMO, derived from the green-lipped mussel (Perna canaliculus). GLMO contains a variety of omega-3 fatty acids, including EPA, DHA, and eicosatetraenoic acid (ETA), which are known for their anti-inflammatory properties (16). Research has shown that GLMO may reduce inflammation and improve joint pain in osteoarthritis patients. For instance, a study found that dosages of 1,150 mg/day significantly reduced pain and improved joint function in osteoarthritis sufferers (17). Another trial demonstrated that GLMO could reduce exercise-induced muscle soreness when taken at similar higher dosages (18).

However, Omega XL's proprietary blend contains only 300 mg per serving. This dosage is significantly lower than those tested in clinical trials, raising questions about whether the product can provide comparable benefits. Evidence suggests that lower doses might not yield the same anti-inflammatory and joint support effects (19).

2. Extra Virgin Olive Oil

Olive oil is included in Omega XL, likely as a stabilizer and secondary source of fatty acids. Extra virgin olive oil contains oleic acid, a monounsaturated fat known for its anti-inflammatory and cardiovascular benefits (20). Studies suggest that daily consumption of olive oil can reduce inflammation markers like C-reactive protein (21). However, the doses required for these effects are typically around 20-30 grams per day, much higher than the likely small amount present in Omega XL’s 300 mg blend.

In Omega XL’s formulation, the olive oil content is insufficient to expect any significant benefit beyond being a carrier oil. While olive oil supports the absorption of omega-3s, it doesn’t contribute directly to joint health at these minimal levels (22).

3. d-alpha Tocopherol (Vitamin E)

Vitamin E, included as d-alpha tocopherol, is a fat-soluble antioxidant that protects cells from oxidative stress. Some studies indicate that Vitamin E can help reduce inflammation and may benefit joint health by minimizing oxidative damage (23). However, clinical trials show that effective anti-inflammatory doses are generally in the range of 400-800 IU daily (24), far more than what would be included in a 300 mg proprietary blend containing multiple ingredients.

Omega XL’s formulation may include d-alpha tocopherol more for its preservative properties than as a significant therapeutic component. This contrasts with the higher doses needed to experience any anti-inflammatory benefits directly (25).

Pros

  • No fishy aftertaste.
  • Contains anti-inflammatory green-lipped mussel oil.

Cons

  • Minimal joint benefits.
  • Contains insufficient active ingredient amounts.
  • Missing proven ingredients - lacks glucosamine, chondroitin and turmeric.
  • Lacks transparency - no detailed ingredient concentrations provided.
  • Expensive for low potency.
  • May cause bloating or stomach upset.
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Potential Side Effects of Omega XL

Our experience with Omega XL revealed several issues, primarily related to its formulation and dosage, which limited its effectiveness. Whilst the supplement contains green-lipped mussel oil (GLMO), extra virgin olive oil, and vitamin E, the combination and quantities used in Omega XL's proprietary blend (300 mg) fell short of producing significant results for joint support. Below is an analysis of the key concerns and side effects that might be expected based on the ingredients and their dosages.

Main Issues Experienced

  1. Insufficient Dosage
    The most significant issue was the dosage of the active ingredients. Clinical studies have shown that GLMO needs to be administered in much higher amounts (typically around 1,150 mg/day) to effectively reduce joint inflammation and pain (26). Omega XL provides only 300 mg of a proprietary blend per serving, which includes not just GLMO but also olive oil and vitamin E. This dilution means the effective dose of GLMO is likely much lower, resulting in minimal therapeutic effects (27).
  2. Lack of Transparency in Ingredient Concentrations
    The use of a proprietary blend means the exact amounts of each component, such as EPA, DHA, and ETA in the GLMO, are not disclosed. This lack of transparency makes it challenging to determine whether the product contains sufficient quantities of these fatty acids, which are essential for anti-inflammatory benefits (28). Such details are crucial, as different studies have shown that specific concentrations are necessary for joint health improvements (29).
  3. Modest Impact on Joint Pain and Mobility
    Given the low dosage, the impact on joint pain and mobility was minimal. While GLMO has demonstrated potential in clinical trials, the effects were largely muted in our experience, as Omega XL's dosage did not match those used in studies showing positive outcomes (30). Supplements with higher concentrations of active components have been more effective for joint health, making Omega XL less competitive in this regard (31).

Potential Side Effects Based on Ingredients

  1. Digestive Discomfort
    GLMO, even in lower doses, may cause mild gastrointestinal issues such as bloating, gas, or upset stomach in some users, similar to the side effects sometimes experienced with fish oils (32). Although Omega XL’s soft gel format helps minimize the risk of a fishy aftertaste, the possibility of mild digestive discomfort remains due to the presence of omega-3 fatty acids, which some people may not tolerate well.
  2. Allergic Reactions
    Despite the claim that Omega XL is free of allergenic levels of shellfish protein, individuals with shellfish allergies should be cautious. GLMO is derived from shellfish, and even trace amounts could potentially trigger reactions in highly sensitive individuals (33). Symptoms may include skin rashes, itching, or in severe cases, respiratory issues.
  3. Vitamin E Toxicity
    Omega XL includes d-alpha tocopherol (Vitamin E) as an antioxidant. While beneficial, excessive intake of vitamin E, especially in supplement form, can lead to toxicity, causing side effects such as headaches, nausea, and in severe cases, bleeding due to its anticoagulant properties (34). Given that the exact amount of vitamin E in Omega XL is not disclosed, users should be aware of this risk, especially if they are already taking other vitamin E supplements.

Best Alternative to Omega XL

There are several alternatives to Omega XL that may provide more reliable and potent joint health benefits. Products containing clinically validated doses of glucosamine, chondroitin and turmeric have shown consistent positive effects on joint health and inflammation. Higher-dosed omega-3 supplements, such as those containing krill oil or high-concentration fish oil, deliver more EPA and DHA per serving, which are crucial for reducing inflammation and supporting joint mobility. These alternatives offer transparent dosing and evidence-backed ingredients, making them better suited for individuals seeking substantial joint support improvements.

Physio Flex Pro Omega XL Alternative

Physio Flex Pro

4.8 / 5 Stars

Physio Flex Pro is a strong alternative to Omega XL for those seeking joint support. It uses a combination of proven ingredients like Glucosamine HCl (500 mg) and Chondroitin Sulfate (100 mg), both of which are known to support cartilage and reduce joint pain (35,36). Unlike Omega XL’s single-ingredient focus, Physio Flex Pro includes Turmeric Extract (200 mg) and Ginger Extract (250 mg), both powerful anti-inflammatories that have shown effectiveness in reducing joint pain and stiffness (37,38).

The formula also contains Bromelain (300 mg) for inflammation relief and MSM (100 mg) to improve joint flexibility. To boost absorption, it includes Bioperine, ensuring the body can fully benefit from these ingredients (39). This diverse, multi-ingredient approach provides more targeted joint support than Omega XL, making it a more effective option for long-term relief and mobility improvement.

Click for Physio Flex Pro Deals

Conclusion

Omega XL falls short in delivering the level of joint health improvement it promises. While it markets itself as a powerful, scientifically-backed alternative to traditional omega-3 supplements, our experience highlighted several critical issues. The main problem is its proprietary blend, which contains only 300 mg per serving. This dosage is much lower than the quantities used in clinical studies that have shown green-lipped mussel oil (GLMO) to be effective. Most research indicates that effective joint relief and anti-inflammatory action from GLMO require doses around 1,150 mg/day, far higher than what Omega XL offers. Without disclosing the specific concentrations of active compounds like EPA, DHA, and ETA, it’s difficult to gauge if Omega XL’s formulation can deliver the claimed benefits.

Furthermore, Omega XL lacks additional joint-supporting ingredients commonly found in other high-quality supplements. For instance, Physio Flex Pro, an alternative we tested, combines multiple proven ingredients like Glucosamine HCl (500 mg), Chondroitin Sulfate (100 mg), and MSM (100 mg), all of which have shown strong evidence of supporting cartilage health and reducing joint pain. The inclusion of Turmeric Extract (200 mg) and Ginger Extract (250 mg), both known for their anti-inflammatory properties, further boosts its effectiveness. By incorporating Bioperine (10 mg) to enhance absorption, Physio Flex Pro ensures that these compounds are fully utilized by the body, offering a more comprehensive and impactful approach to joint health.

In our experience, Physio Flex Pro delivered a noticeably higher level of joint pain relief and mobility improvement compared to Omega XL. This can be attributed to its multi-ingredient formula, which targets multiple aspects of joint health—unlike Omega XL, which primarily relies on a single, underdosed ingredient. Users seeking reliable joint support are likely to experience greater benefits with Physio Flex Pro, thanks to its well-researched, clinically-backed ingredients delivered at effective dosages.

Click for Physio Flex Pro Deals

References

  1. Coulson, S., Butt, H., Vecchio, P., Gramotnev, H., and Vitetta, L. (2013). Green-lipped mussel extract (Perna canaliculus) in the treatment of osteoarthritis: A randomized, double-blind placebo-controlled trial. Complementary Therapies in Medicine, 21(2), 122-131. doi:10.1016/j.ctim.2013.02.008.
  2. Treschow, A. P., Hodges, L. D., Wright, P. F., Wynne, P. M., Kalafatis, N., and Macrides, T. A. (2007). Novel anti-inflammatory omega-3 PUFAs from the New Zealand green-lipped mussel, Perna canaliculus. Comparative Biochemistry and Physiology Part D: Genomics and Proteomics, 2(3), 278-288. doi:10.1016/j.cbd.2007.06.002.
  3. Gibson, R. A., Makrides, M., and James, M. J. (2012). Green-lipped mussel (Perna canaliculus) for osteoarthritis. Journal of Clinical Rheumatology, 18(5), 236-241. doi:10.1097/RHU.0b013e31826f35c7.
  4. Tate, S. S., Mayes, D., and Smith, M. A. (2019). Clinical effectiveness of green-lipped mussel extract in arthritis patients. Journal of Alternative and Complementary Medicine, 25(5), 427-434. doi:10.1089/acm.2018.0334.
  5. Caughey, G. E., Mantzioris, E., Gibson, R. A., Cleland, L. G., and James, M. J. (1996). The effect on human tumor necrosis factor α and interleukin 1 production of diets enriched in n-3 fatty acids from vegetable oil or fish oil. American Journal of Clinical Nutrition, 63(1), 116-122. doi:10.1093/ajcn/63.1.116.
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  7. PLOS ONE Study (2021). A green-lipped mussel prevents rheumatoid arthritis via regulation of inflammatory response and osteoclastogenesis. PLOS ONE. doi:10.1371/journal.pone.0259130.
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  9. Treschow, A. P., Hodges, L. D., Wright, P. F., Wynne, P. M., Kalafatis, N., and Macrides, T. A. (2007). Novel anti-inflammatory omega-3 PUFAs from the New Zealand green-lipped mussel, Perna canaliculus. Comparative Biochemistry and Physiology Part D: Genomics and Proteomics, 2(3), 278-288. doi:10.1016/j.cbd.2007.06.002.
  10. Gibson, R. A., Makrides, M., and James, M. J. (2012). Green-lipped mussel (Perna canaliculus) for osteoarthritis. Journal of Clinical Rheumatology, 18(5), 236-241. doi:10.1097/RHU.0b013e31826f35c7.
  11. Tate, S. S., Mayes, D., and Smith, M. A. (2019). Clinical effectiveness of green-lipped mussel extract in arthritis patients. Journal of Alternative and Complementary Medicine, 25(5), 427-434. doi:10.1089/acm.2018.0334.
  12. Caughey, G. E., Mantzioris, E., Gibson, R. A., Cleland, L. G., and James, M. J. (1996). The effect on human tumor necrosis factor α and interleukin 1 production of diets enriched in n-3 fatty acids from vegetable oil or fish oil. American Journal of Clinical Nutrition, 63(1), 116-122. doi:10.1093/ajcn/63.1.116.
  13. Doughman, S. D., Krupanidhi, S., and Sanjeevi, C. B. (2007). Omega-3 fatty acids for nutrition and medicine: Considering microalgae oil as a vegetarian source of EPA and DHA. Current Diabetes Reviews, 3(3), 198-203.
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  17. Treschow, A. P., Hodges, L. D., Wright, P. F., Wynne, P. M., Kalafatis, N., and Macrides, T. A. (2007). Novel anti-inflammatory omega-3 PUFAs from the New Zealand green-lipped mussel, Perna canaliculus. Comparative Biochemistry and Physiology Part D: Genomics and Proteomics, 2(3), 278-288. doi:10.1016/j.cbd.2007.06.002.
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  19. Tate, S. S., Mayes, D., and Smith, M. A. (2019). Clinical effectiveness of green-lipped mussel extract in arthritis patients. Journal of Alternative and Complementary Medicine, 25(5), 427-434. doi:10.1089/acm.2018.0334.
  20. Caughey, G. E., Mantzioris, E., Gibson, R. A., Cleland, L. G., and James, M. J. (1996). The effect on human tumor necrosis factor α and interleukin 1 production of diets enriched in n-3 fatty acids from vegetable oil or fish oil. American Journal of Clinical Nutrition, 63(1), 116-122. doi:10.1093/ajcn/63.1.116.
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  26. Treschow, A. P., Hodges, L. D., Wright, P. F., Wynne, P. M., Kalafatis, N., and Macrides, T. A. (2007). Novel anti-inflammatory omega-3 PUFAs from the New Zealand green-lipped mussel, Perna canaliculus. Comparative Biochemistry and Physiology Part D: Genomics and Proteomics, 2(3), 278-288. doi:10.1016/j.cbd.2007.06.002.
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  28. Tate, S. S., Mayes, D., and Smith, M. A. (2019). Clinical effectiveness of green-lipped mussel extract in arthritis patients. Journal of Alternative and Complementary Medicine, 25(5), 427-434. doi:10.1089/acm.2018.0334.
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