Avocado Soybean Unsaponifiables (ASU) have been increasingly gaining attention for their potential benefits in promoting joint health. Extracted from the unsaponifiable fractions of avocado and soybean oils, ASU is a natural supplement that has been researched for its effects on managing osteoarthritis and reducing joint pain. Preliminary studies suggest that the anti-inflammatory properties of ASU might aid in reducing the symptoms of joint-related disorders, providing a potential alternative option for those seeking relief.

As osteoarthritis affects millions of people worldwide, the need for effective treatment options becomes imperative. ASU has demonstrated promising results in alleviating joint pain, with research pointing out possible structural effects on joint space loss in osteoarthritis of the hip. This novel approach to joint health management could offer a more natural alternative to conventional treatments, while also highlighting the importance of proper diet and exercise in maintaining optimal joint health.

Key Takeaways

Overview of Avocado Soybean Unsaponifiables

What Are Avocado Soybean Unsaponifiables

Avocado Soybean Unsaponifiables, often referred to as ASU, are natural extracts derived from the oils of avocados and soybeans. These extracts are composed of the unsaponifiable fractions of the two oils, which are rich in bioactive substances like phytosterols, tocopherols, and triterpenic alcohols. ASU has gained attention in recent years for its potential health benefits, particularly in supporting joint health.

ASU as a Dietary Supplement

The popularity of ASU as a dietary supplement is mainly due to its potential benefits for those suffering from joint pain and osteoarthritis. Some research suggests that ASU may help to reduce inflammation, improve joint function, and potentially slow down the progression of osteoarthritis. This makes it an attractive option for those looking for natural, safe, and effective treatments for joint pain.

In addition to joint health, ASU has been found to possess a range of other health-promoting properties. Some studies indicate that it may have antioxidant, anti-inflammatory, and even cardio-protective effects, making it a versatile supplement with multiple potential benefits.

When selecting an ASU supplement, it’s essential to choose a high-quality product from a reputable manufacturer, as the composition and efficacy of ASU can vary significantly depending on the extraction method and quality of the raw materials used. By incorporating ASU into a healthy lifestyle, individuals may experience improved joint health and overall well-being.

Joint Health and Osteoarthritis

Symptoms of Osteoarthritis

Osteoarthritis (OA) is a common degenerative joint disease that affects millions of people worldwide. It can occur in various joints, but it’s most commonly seen in the knees and hips. Some common symptoms of OA include:

  • Pain and stiffness in the affected joints, particularly during physical activity or after periods of inactivity
  • Swelling and inflammation, which can lead to joint inflammation
  • Reduced range of motion or flexibility in the joint
  • Formation of bone spurs around the joint edges
  • Cartilage loss, causing bones to rub against each other

Causes and Risk Factors

There are several factors that can contribute to the development of osteoarthritis, including:

  • Age: The risk of developing OA increases as we age due to the natural wear and tear on our joints.
  • Genetics: Some people may have a genetic predisposition to developing OA.
  • Obesity: Excess weight adds more stress to the joints, particularly the knee and hip joints, accelerating cartilage loss and inflammation.
  • Injury or overuse: Previous joint injuries or repeated stress on certain joints from sports or work activities can increase the risk of OA.
  • Joint malalignment: Misaligned joints can cause uneven distribution of weight and stress, leading to cartilage degradation and joint inflammation.
  • Gender: Women are more likely to develop OA than men, although the reasons for this are not yet fully understood.

Several lifestyle changes can help manage osteoarthritis and improve joint health. These include:

  • Weight control: Maintaining a healthy weight can reduce stress on the joints and slow OA progression.
  • Exercise: Low-impact activities such as swimming, cycling, and walking can help strengthen muscles, improve flexibility, and reduce joint stiffness.
  • Joint protection: Supportive devices like braces or shoe inserts can help protect and stabilize affected joints during activity.

Recent research has shown that Avocado Soybean Unsaponifiables (ASU) may be beneficial for individuals with osteoarthritis, showing ability to reduce pain and inflammation and potentially even slow joint space loss in hip osteoarthritis. ASU is a natural extract derived from avocado and soybean oils, offering an additional tool to help manage and support joint health.

ASU and Its Effects on Joint Health

Avocado Soybean Unsaponifiables (ASU) is a dietary supplement derived from avocado and soybean oil extracts, which has been shown to have potential benefits for joint health. This section will focus on some of the most significant findings regarding ASU and its effects on joint health, covering the reduction of inflammation and pain, cartilage repair and protection, and clinical trials and evidence.

Reduction of Inflammation and Pain

ASU has been reported to have anti-inflammatory properties that can help alleviate joint pain and inflammation in conditions like arthritis. ASU’s anti-inflammatory effects have been attributed to its ability to inhibit pro-inflammatory molecules like interleukins and prostaglandins, which contribute to joint pain and damage in arthritis patients (source). ASU has been found to alleviate knee and hip joint pain, reducing stiffness, and improving mobility in people with arthritis.

Cartilage Repair and Protection

One of the main focuses of joint health is the maintenance of cartilage, which acts as a cushion between bones, and can be damaged in conditions like osteoarthritis. ASU has been observed to help protect cartilage by inhibiting the breakdown of certain connective tissue components and promoting cartilage repair processes (source). Furthermore, ASU has been compared to other dietary supplements like glucosamine and chondroitin for its ability to preserve cartilage structure and slow down cartilage degradation. The potential cartilage-protective effects of ASU may help maintain joint function over time in individuals with joint degeneration.

Clinical Trials and Evidence

Numerous clinical trials have explored the efficacy of ASU in improving joint health. In a meta-analysis of randomized controlled trials, ASU was shown to help alleviate pain and improve joint function in osteoarthritis patients (source).

In one study, the ASU product Piascledine was evaluated for its long-term effects on hip joint space narrowing, which is indicative of cartilage loss. The results suggested that, while ASU did not halt the progression of joint space loss, it did help slow down the rate of joint space narrowing (source).

Moreover, another study examined the effects of the ASU product Arthrocen on joint pain and inflammation in a rat model of osteoarthritis. Arthrocen capsules showed a reduction in pain scores on the visual analog scale after 6 months of treatment (source).

In conclusion, ASU may offer potential benefits for joint health, particularly in alleviating pain and inflammation, and promoting cartilage repair and protection. While clinical trial results have been promising, it is essential to note that ASU is not a replacement for anti-inflammatory medications, such as nonsteroidal anti-inflammatory drugs (NSAIDs), or other treatments like hyaluronic acid injections and weight loss management. However, as a part of a comprehensive treatment approach, ASU may contribute to improved joint health in individuals suffering from joint-related issues.

Comparing ASU to Other Treatment Options

Glucosamine and Chondroitin

Glucosamine and chondroitin are popular supplements for joint health, often used to treat symptoms of osteoarthritis. While these supplements have shown some potential benefits for joint pain and inflammation, they may not be as effective in preventing joint damage. Avocado soybean unsaponifiables (ASUs), on the other hand, have shown promise in not only reducing pain and stiffness but also in improving joint function.

NSAIDs and Analgesics

Nonsteroidal anti-inflammatory drugs (NSAIDs) and analgesics, such as acetaminophen, are commonly used to manage pain and inflammation in osteoarthritis. However, long-term use of these medications can result in side effects like gastrointestinal issues and liver damage. ASU provides a more natural alternative for managing joint pain and has been shown to decrease NSAID intake over time.

Alternative Therapies

There are several alternative therapies for osteoarthritis, including:

While these alternatives may provide relief for some individuals, ASU is a unique option due to its combination of avocado and soybean extracts. This blend has demonstrated symptomatic efficacy in treating the pain and joint deterioration associated with osteoarthritis.

Safety and Side Effects of ASU

Avocado Soybean Unsaponifiables (ASU) are a natural product derived from vegetable extracts, often used to support joint health. ASU is generally considered safe, but there are potential side effects, drug interactions, allergies and precautions that should be taken into account.

Common Side Effects

Although ASU is considered a safe supplement, some users might experience side effects. The most common side effects reported by ASU users are mild gastrointestinal complaints, such as stomach discomfort, diarrhea, or constipation1. However, the frequency of these side effects is relatively low, with some studies suggesting that there were no significant differences in adverse effects between ASU and placebo groups2. Patients with existing gastrointestinal problems should consult their healthcare provider before starting ASU.

Drug Interactions

While ASU has not been shown to have widespread drug interactions, it might interact with certain medications, such as warfarin, a common anticoagulant. The vitamin E content in ASU capsules may have a potential to interfere with the efficacy of warfarin and increase the risk of bleeding3. Individuals taking warfarin or other blood-thinning medications should consult with their healthcare provider before starting ASU supplementation.


People with known allergies to avocado, soybean, or any of the other compounds found in ASU supplement should avoid taking it4. Although allergic reactions to ASU are rare, they can occur and may result in symptoms like hives, difficulty breathing, or swelling of the face, lips, or tongue. If any of these symptoms occur, discontinue the use of ASU and seek medical attention immediately.


In general, ASU is considered safe for most individuals. However, some precautions are advised. Pregnant or breastfeeding women should consult their healthcare provider before starting ASU, as the safety of ASU during pregnancy and lactation has not been adequately researched. Additionally, individuals with a history of back pain or other joint issues should be cautious with their ASU dosage and discuss any concerns with their healthcare providers5.

Lifestyle Changes and Exercise for Joint Health

Incorporating lifestyle changes and exercise for joint health is essential in effectively managing joint pain and inflammation. Specific habits play crucial roles in improving joint function and reducing the risk of osteoarthritis progression.

Weight Control

Maintaining a healthy weight can significantly impact joint health. Excess weight puts more strain on the joints, leading to increased pain and inflammation, especially in weight-bearing joints like the knees and hips. Weight control is crucial for reducing pain and preventing further joint damage. Americans can benefit from healthier diets that use options like soybean oil which is a component of Avocado Soybean Unsaponifiables (ASUs). Along with a balanced diet, regular exercise and physical activity can help achieve and maintain an ideal weight.

Physical Therapy

Physical therapy plays an essential role in maintaining joint health. PT offers numerous exercises that can alleviate joint pain and improve functionality. Here are some of the activities that can be incorporated into a physical therapy regimen:

  • Walking: A low-impact exercise that improves circulation and strengthens muscles and joints. Walking can be performed at a comfortable pace and gradually increased in time and distance.
  • Cycling: This activity allows the joints to move in a smooth, continuous motion, with minimal impact. Cycling, whether stationary or outdoors, can increase strength and flexibility in the affected joints.
  • Swimming and Water Aerobics: Swimming is a low-impact exercise that helps improve joint function by allowing smooth, gentle movements without putting pressure on the joints. Water aerobics involves performing resistance exercises in water, providing both cardiovascular and muscle-strengthening benefits.
  • Range-of-motion exercises: These exercises help maintain or improve the flexibility of the joints by gently moving them through their full range of motion. They can be performed daily to alleviate stiffness and pain.

Lifestyle changes, including weight control and physical therapy, can significantly enhance joint health and relieve pain. By incorporating activities like walking, cycling, swimming, and water aerobics, individuals can reduce swelling and experience more flexible, healthier joints. Additionally, using supplements like ASUs, which contain avocado and soybean oil, can further support joint health and act as complementary therapies to these essential lifestyle modifications.


Avocado Soybean Unsaponifiables (ASU) have shown promise in improving joint health and reducing pain in several studies. A meta-analysis of randomized controlled trials suggests that ASUs could be effective in reducing joint pain and inflammation related to osteoarthritis (OA). Furthermore, a study in a rat model of osteoarthritis found that ASU treatment helped alleviate joint pain and inflammation.

ASUs also appear to have a positive effect on factors that contribute to joint deterioration. For example, their use has been associated with a reduction in the expression of pro-inflammatory mediators, such as TNF-α, IL-1β, COX-2, and iNOS, as well as a decrease in prostaglandin E2 and nitric oxide production in the joint, according to a study published in the journal Chondrocyte. This anti-inflammatory action may help protect cartilage and slow joint space loss in cases of OA, as demonstrated in a study on osteoarthritis of the hip.

In addition, a study combining ASUs with epigallocatechin gallate (EGCG) found that this combination effectively inhibited the expression of several pro-inflammatory mediators. This suggests that the synergistic use of ASUs and other natural compounds could potentially enhance their therapeutic benefits for joint health.

In conclusion, Avocado Soybean Unsaponifiables can be considered a promising, natural option for promoting joint health and reducing OA symptoms. Further research is required to better understand the specific mechanisms behind their beneficial effects and to establish optimal dosing regimens.

Frequently Asked Questions

What are the benefits of ASU for joint health?

Avocado Soybean Unsaponifiables (ASU) have shown to possess potential benefits for joint health. ASU may help inhibit cartilage degradation and promote cartilage repair, providing relief from joint pain and improving overall function in individuals with osteoarthritis source.

Where can I purchase ASU supplements?

ASU supplements can be found at various health stores, pharmacies, and online retailers. It’s essential to purchase from a reputable source to ensure high-quality and effective supplements.

Are there any side effects of taking ASU?

ASU is typically considered safe for most people. However, there have been occasional reports of stomach discomfort, nausea, and headaches. If you experience any adverse side effects, consult with a healthcare professional before continuing use.

Is ASU effective for treating osteoarthritis?

Research has shown that ASU may provide symptom-modifying effects when used as a treatment for knee osteoarthritis. Patients adhering to a 6-month treatment demonstrated a significant improvement in pain and overall joint function source. Although more research is needed to confirm its overall efficacy, early findings seem promising.

Can ASU be safely used for dogs?

There is limited research on the use of ASU in dogs. However, some veterinarians recommend it as a supplement to support joint health in dogs, particularly those with arthritis or other joint issues. Always consult with a veterinarian before administering ASU to your pet.

Are ASU supplements available in powder form?

ASU supplements are typically available in various forms, including capsules, tablets, and powders. The choice between these forms depends on personal preferences and how easy it is for you to incorporate the supplement into your daily routine.


  1. Efficacy and safety of avocado‐soybean unsaponifiables ↩

  2. Symptomatic efficacy of avocado/soybean unsaponifiables ↩

  3. Management of osteoarthritis with avocado/soybean unsaponifiables ↩

  4. Avocado–soybean unsaponifiables: a panoply of potentialities to be exploited ↩

  5. Structural effect of avocado/soybean unsaponifiables on joint space loss in osteoarthritis of the hip ↩